Sydney (Australia)
A commonly prescribed rheumatoid arthritis drug can suppress the progression of Type 1 diabetes, according to results of the world-first human trial.
The ground-breaking research shows promise as the first disease-modifying treatment of its kind for Type 1 diabetes that can be delivered as a tablet.
The findings, published in the New England Journal of Medicine, showed that the drug called baricitinib can safely and effectively preserve the body’s own insulin production and suppress the progression of Type 1 diabetes in people who initiated treatment within 100 days of diagnosis.
“When type 1 diabetes is first diagnosed there is a substantial number of insulin-producing cells still present. We wanted to see whether we could protect further destruction of these cells by the immune system,” said Prof. Thomas Kay from St Vincent’s Institute of Medical Research (SVI) in Melbourne, Australia.
"We showed that baricitinib is safe and effective at slowing the progression of Type 1 diabetes in people who have been recently diagnosed,” added Kay.
So far, people with Type 1 diabetes have been reliant on insulin delivered via injection or infusion pump.
The trial showed that, if started early enough after diagnosis, and while the participants remained on the medication, their production of insulin was maintained.
“People with Type 1 diabetes in the trial who were given the drug required significantly less insulin for treatment,” Kay said.
Management of the lifelong autoimmune disease is incredibly burdensome on those diagnosed and their families, requiring meticulous glucose monitoring and insulin administration day and night to stay alive.
Up until insulin’s discovery more than 100 years ago, Type 1 diabetes was a fatal condition.
Despite insulin’s life-saving role, the therapy itself is potentially dangerous if too much or too little is administered, and the condition still comes with long-term complications, including heart attack and stroke, vision impairment, kidney disease and nerve damage.
“We are very optimistic that this treatment will become clinically available. This would be a huge step-change in how type 1 diabetes is managed and we believe it shows promise as a fundamental improvement in the ability to control type 1 diabetes,” said Prof. Helen Thomas, preclinical lead on the trial.
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