Saquib Salim

Genes and DNA are the words we hear frequently on our Televisions and other media. Genetic mapping has revolutionised the way humans understand organisms in general and themselves in particular. The past few decades have witnessed developments in biotechnology and genetics leading us to understand and treat diseases hitherto thought curable. Very few among us know that one of the important men who laid the foundation of this revolution was an Indian, Obaid Siddiqui.

Born on this day in 1932 in Basti, Uttar Pradesh, Obaid Siddiqui completed his Masters in Botany from Aligarh Muslim University (AMU) in 1953. Initially, he joined AMU as an agricultural scientist, after his Masters, and later moved to Indian Agriculture Research Institute (IARI), New Delhi. At IARI Siddiqui had prepared a testbed for wheat crossbreeds. But a devastating hail storm destroyed the crop and ruined his year-long labour. A frustrated Siddiqui, who had a keen interest in genetics, an emerging field at the time, wrote a letter to Professor Guido Pontecorvo at Glasgow asking him for a research opportunity with him. Pontecorvo accepted him and Siddiqui started his PhD at Glasgow on microbial systems - a paradigm shift from Botany.

During his PhD, Obaid made some path-breaking observations, which revolutionised the field of Genetics. Two very important observations made by him  were:

• His studies were the first reports of fine mapping of a gene.
• He pointed out the concentration of mutational sites in a small part of genes.

Obaid Siddiqui with Semour Benzer

So, when he submitted his PhD thesis in 1961 Siddiqui had already revolutionised the sciences in general and genetics in particular. Considering the fact that he shifted from Botany to a different field makes his achievement even more stellar.

The same year Siddiqui moved to Pennsylvania to work with Alan Garen as a postdoctoral fellow. Here, he discovered the suppressors of “nonsense” mutations. In simpler words, he discovered why a few mutations in a gene would not express themselves and remain suppressed. The discovery was a logical result of his earlier pioneering work in mapping of genes. Another important impact of this discovery was the finding of “nonsense” codons, the stop signal of genes. Har Gobind Khorana, Robert Holley, and Marshall Nirenberg received the 1968 Nobel prize for identifying “nonsense” codons and they personally acknowledged the role of Siddiqui in their research.

Siddiqui did not pursue his study of Codons further which got others a Nobel Prize because his heart was not in the USA. Siddiqui wanted to return to India to serve his motherland. This selfless patriot left the lucrative opportunities and told Alan Garen, in 1962, that he wanted to return to India. Garen asked renowned physicist Leo Szilard to write to Homi Bhabha asking him to arrange a position for Siddiqui in India. Ignoring the opposition from fellow scientists in India, Bhabha showed confidence in Siddui and gave him the responsibility of establishing a molecular biology unit at Tata Institute of Fundamental Research (TIFR).

Obaid ASiddiqui with Wife Asiya Siddiqui

At TIFR, Siddiqui nurtured a younger crop of scientists and also brought Indians working in foreign labs back to India. With one of his students, P. Vijay Sarathy, Siddiqui showed that recombinant bacteria inherit DNA of bi-parental origin thus laying the foundation of principles of lateral gene transfer. In layman’s language his findings are the basis of the now well-known principle that genes pass from one generation to another.

With his other students like Kavita Arora and Veronica Rodrigues, Siddiqui showed that taste and smell of Drosophila have a genetic basis and thus opened a new field of chemosensory neurogenetics. These findings led others to research the role of genes on sensory perceptions, learning and memory.

Siddiqui was not a man who would compartmentalize his intellect to one branch of science. He contributed to fields as diverse as plants, Drosophila, bacteria, and genetics. He did not stop at research. He was an institution builder and established the National Centre for Biological Sciences in 1992 in Bangalore. Siddiqui was known for nurturing young minds by giving them the freedom to question.

Moreover, Siddiqui was a man who believed that sciences cannot operate in isolation of society. Scientists have a social responsibility and Siddiqui understood this. He stood for Human Rights, campaigned against communalisation and took part in social movements. Not only a music lover of Hindustani Music, Siddiqui was an established Sarod artist.

Obaid Siddiqui was awarded the second-highest civilian award, Padm Vibhusahan, by the Government of India. He was the true son of the soil who left lucrative offers in a foreign land to establish a research culture in India. His students are now serving the nation, which includes the present Principal Scientific Advisor of India, Professor Vijay Raghavan.